{"id":39,"date":"2021-03-11T14:14:24","date_gmt":"2021-03-11T13:14:24","guid":{"rendered":"http:\/\/afpcahome\/site\/?page_id=39"},"modified":"2024-05-07T17:30:29","modified_gmt":"2024-05-07T15:30:29","slug":"quelle-est-la-cause","status":"publish","type":"page","link":"https:\/\/afpca.fr\/site\/quelle-est-la-cause\/","title":{"rendered":"Quelle est la cause ?"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"39\" class=\"elementor elementor-39\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bef5863 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bef5863\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7d1af0\" data-id=\"d7d1af0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-947951f elementor-widget elementor-widget-image\" data-id=\"947951f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/afpca.fr\/site\/wp-content\/uploads\/elementor\/thumbs\/heart-665183_1920-p40u4897q54nd9abk802nwfb66uce65oqmv29206og.jpg\" title=\"heart-665183_1920\" alt=\"heart-665183_1920\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-73061b2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"73061b2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b4892dd\" data-id=\"b4892dd\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4a1dff1 elementor-widget elementor-widget-text-editor\" data-id=\"4a1dff1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La PCA est une maladie inflammatoire, auto-immune, polyfactorielle probable, d\u2019origine inconnue dont les facteurs d\u00e9clenchants et la physiopathologie restent \u00e0 pr\u00e9ciser.<\/p><p>Elle semble r\u00e9sulter de l\u2019agression des propres constituants cartilagineux de l\u2019organisme (qui font partie des antig\u00e8nes du \u00ab soi \u00bb) par le syst\u00e8me immunitaire, qui est normalement charg\u00e9 de le d\u00e9fendre.<\/p><p>On assiste donc \u00e0 une rupture de la \u00ab tol\u00e9rance \u00bb de celui-ci. Ce syst\u00e8me fonctionne par exc\u00e8s avec production, par les lymphocytes B \u00ab auto-r\u00e9actifs \u00bb, d\u2019auto-anticorps dirig\u00e9s contre les propres constituants cartilagineux de l\u2019organisme et activation de populations de lymphocytes T \u00abauto-r\u00e9actifs\u00bb impliqu\u00e9s dans la r\u00e9action inflammatoire et les l\u00e9sions tissulaires.<\/p><p>Comme dans bon nombre de maladies auto-immunes, une interaction entre ces deux populations de lymphocytes dits \u00ab auto-r\u00e9actifs \u00bb est mise en jeu.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-aaf6beb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aaf6beb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f5737ec\" data-id=\"f5737ec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-047e1cb elementor-widget elementor-widget-heading\" data-id=\"047e1cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">C'est une maladie auto-immune<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1824efd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1824efd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-93eaf51\" data-id=\"93eaf51\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3d3d7f6 elementor-widget elementor-widget-text-editor\" data-id=\"3d3d7f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\">Plusieurs facteurs renforcent cette hypoth\u00e8se :<br \/>\u00a0 \u00a0\u2022 L\u2019existence dans 30 % des cas de maladies auto-immunes associ\u00e9es ;<br \/>\u00a0 \u00a0\u2022 L\u2019existence, parfois, d\u2019ant\u00e9c\u00e9dents de maladies auto-immunes dans les ascendants ou la fratrie ;<br \/>\u00a0 \u00a0\u2022 La d\u00e9couverte chez certains patients d\u2019anticorps dirig\u00e9s contre les prot\u00e9ines de la matrice du cartilage (anticorps anti-collag\u00e8ne de type II, IX et XI et anticorps anti-matriline) ;<br \/>\u00a0 \u00a0\u2022 La pr\u00e9sence de d\u00e9p\u00f4ts de complexes immuns au niveau des l\u00e9sions chondritiques ;<br \/>\u00a0 \u00a0\u2022 La mise en \u00e9vidence d&#8217;une r\u00e9ponse lymphocytaire T sp\u00e9cifique du collag\u00e8ne de type II ;<br \/>\u00a0 \u00a0\u2022 La possibilit\u00e9 de reproduire la maladie chez la souris apr\u00e8s immunisation par le collag\u00e8ne de type II ;<br \/>\u00a0 \u00a0\u2022 L\u2019efficacit\u00e9 des traitements par cortico\u00efdes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-df84938 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"df84938\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-48b4c87\" data-id=\"48b4c87\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c77fa0a elementor-widget elementor-widget-heading\" data-id=\"c77fa0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">C'est une maladie inflammatoire<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c9b5948 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c9b5948\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-37a2d47\" data-id=\"37a2d47\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0e7ec7e elementor-widget elementor-widget-text-editor\" data-id=\"0e7ec7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Comme pour toutes les pathologies auto-immunes, la r\u00e9action initiale \u00e0 une agression tissulaire est de type inflammatoire, sous-tendue par une cascade d\u2019\u00e9v\u00e8nements amplifiant la r\u00e9ponse en exc\u00e8s du syst\u00e8me immunitaire qui se retourne contre les propres constituants de l\u2019organisme.<br \/>Dans la PCA ce sont les tissus cartilagineux qui sont la cible et le si\u00e8ge de l\u00e9sions inflammatoires avec pour corollaires cliniques : douleur, rougeur et parfois gonflement.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f850ecb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f850ecb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7d758a8\" data-id=\"7d758a8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-51f7e7a elementor-widget elementor-widget-heading\" data-id=\"51f7e7a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">C'est une maladie polyfactorielle<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-762e18b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"762e18b\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-05edb44\" data-id=\"05edb44\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-39fe1c9 elementor-widget elementor-widget-text-editor\" data-id=\"39fe1c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Il existe des facteurs g\u00e9n\u00e9tiques, en fait des g\u00e8nes de susceptibilit\u00e9 impliqu\u00e9s dans la r\u00e9ponse du syst\u00e8me immunitaire. Mais ce n\u2019est pas une maladie h\u00e9r\u00e9ditaire. Ceci explique les cas familiaux, cependant rares, retrouv\u00e9s. Ces g\u00e8nes \u00e9tant pr\u00e9sents chez des individus indemnes de maladie, ils ne peuvent \u00e0 eux seuls d\u00e9clencher la PCA. Les g\u00e8nes impliqu\u00e9s font partie du syst\u00e8me majeur d\u2019histocompatibilit\u00e9 (CMH) et concernent les antig\u00e8nes HLA (human leucocyte antigen) de classe II qui sont des prot\u00e9ines de surface port\u00e9es par les globules blancs. L\u2019association de la PCA avec certains de ces antig\u00e8nes HLA a \u00e9t\u00e9 rapport\u00e9e.<br \/>Des facteurs psychologiques en tant que facteurs d\u00e9clenchants de pouss\u00e9es mais sans relation causale directe peuvent \u00eatre discut\u00e9s lors d\u2019une pouss\u00e9e de PCA qui suit un deuil, une intervention chirurgicale, un \u00e9tat d\u00e9pressif ou tout autre traumatisme affectif.<br \/>Des facteurs hormonaux, infectieux ou autres facteurs environnementaux (toxiques, m\u00e9dicaments\u2026) restent \u00e0 pr\u00e9ciser ou \u00e0 identifier.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8507fb6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8507fb6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2e802f5\" data-id=\"2e802f5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4f36797 elementor-widget elementor-widget-heading\" data-id=\"4f36797\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PCA et h\u00e9mopathie ?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-92d66bc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"92d66bc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8c6f294\" data-id=\"8c6f294\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e7a94bf elementor-widget elementor-widget-text-editor\" data-id=\"e7a94bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La PCA peut dans de rares cas \u00eatre induite par (ou associ\u00e9e \u00e0) une h\u00e9mopathie (maladie du sang). Ainsi, elle peut pr\u00e9c\u00e9der (plus rarement suivre) l\u2019installation d\u2019une maladie de la mo\u00eblle osseuse (syndrome my\u00e9lodysplasique) surtout chez l\u2019homme \u00e0 partir de 60 ans.<\/p><p><strong>Beaucoup d\u2019inconnues subsistent en ce qui concerne :<br \/><\/strong>\u00a0 \u00a0\u2022 l\u2019agent causal initial responsable de la r\u00e9ponse immunitaire anormale ;<br \/>\u00a0 \u00a0\u2022 la balance exacte entre le r\u00f4le des lymphocytes B et T ;<br \/>\u00a0 \u00a0\u2022 l\u2019influence des diff\u00e9rents facteurs d\u00e9clenchants.<\/p><p><strong>Seule la recherche fondamentale et les progr\u00e8s dans la connaissance de la physiopathologie de la PCA, ainsi que les progr\u00e8s dans la connaissance des pathologies auto-immunes, permettront de comprendre et donc d\u2019esp\u00e9rer une th\u00e9rapeutique plus cibl\u00e9e et plus efficace.<\/strong><\/p><p>Participez aux recherches et aidez les malades en faisant un don \u00e0 l&#8217;AFPCA,\u00a0 Cliquer sur &#8220;<a href=\"https:\/\/afpca.fr\/site\/adhesion\/\">nous soutenir&#8221;<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La PCA est une maladie inflammatoire, auto-immune, polyfactorielle probable, d\u2019origine inconnue dont les facteurs d\u00e9clenchants et la physiopathologie restent \u00e0 pr\u00e9ciser. Elle semble r\u00e9sulter de l\u2019agression des propres constituants cartilagineux de l\u2019organisme (qui font partie des antig\u00e8nes du \u00ab soi \u00bb) par le syst\u00e8me immunitaire, qui est normalement charg\u00e9 de le d\u00e9fendre. On assiste donc [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry","post"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Quelle est la cause ? - Association Francophone Contre La Polychondrite Chronique Atrophiante -<\/title>\n<meta name=\"description\" content=\"C&#039;est une maladie auto-immune syst\u00e9mique rare : La PCA est une maladie inflammatoire, auto-immune, poly factorielle probable, d\u2019origine inconnue dont les facteurs d\u00e9clenchants et la physiopathologie restent \u00e0 pr\u00e9ciser.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afpca.fr\/site\/quelle-est-la-cause\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Quelle est la cause ? 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