{"id":506,"date":"2021-03-11T14:43:23","date_gmt":"2021-03-11T13:43:23","guid":{"rendered":"http:\/\/afpcahome\/site\/?page_id=506"},"modified":"2024-05-07T13:01:07","modified_gmt":"2024-05-07T11:01:07","slug":"les-corticoides","status":"publish","type":"page","link":"https:\/\/afpca.fr\/site\/les-corticoides\/","title":{"rendered":"Les Cortico\u00efdes"},"content":{"rendered":"\t\t
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L’ action des cortico\u00efdes est antalgique, anti-inflammatoire et immunosuppressive. Elle est identique \u00e0 celle des hormones cortico\u00efdes naturelles produites par les glandes surr\u00e9nales (cortisol).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"thermometer-1539191_1920\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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La pr\u00e9dnisone<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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C’est le traitement de base de la PCA et de nombreuses autres maladies inflammatoires et auto-immunes.<\/p>

Administr\u00e9e par voie orale\u00a0: comprim\u00e9s dos\u00e9s \u00a0\u00e0 1mg, 5 mg et 20 mg.<\/span><\/h5>

Le dosage en p\u00e9riode de pouss\u00e9e est de 1 mg\/kg\/jour pour les adultes. Et la dose d\u2019entretien est de 0.25 mg\/kg\/jour. Ce traitement varie en fonction du poids de l\u2019individu, mais aussi de la s\u00e9v\u00e9rit\u00e9 de la pouss\u00e9e et de l\u2019organe impliqu\u00e9. Il peut \u00eatre prescrit pendant des mois ou des ann\u00e9es et d\u00e9pend de l\u2019\u00e9volution de la maladie.<\/p>

Son efficacit\u00e9 est reconnue dans les chondrites, l\u2019atteinte poly-articulaire, oculaire, laryngo-trach\u00e9ale, r\u00e9nale ou neurologique.<\/p>

Quelques r\u00e8gles importantes \u00e0 respecter par les patients sous prednisone\u00a0:<\/p>

Ne jamais augmenter ou diminuer le dosage sans approbation du m\u00e9decin.<\/p>

Ne jamais arr\u00eater brutalement de prendre ce m\u00e9dicament. Bien souvent la production naturelle par les glandes surr\u00e9nales (inhib\u00e9e par la corticoth\u00e9rapie au long cours) peut ne pas red\u00e9marrer correctement. Un arr\u00eat brutal peut donc mettre la vie en danger et provoquer \u00a0par ailleurs une pouss\u00e9e de PCA en cas de corticod\u00e9pendance.<\/p>

Suivre un r\u00e9gime alimentaire sans sel et sans sucre.<\/p>

Les effets secondaires\u00a0possibles de la Prednisone,\u00a0notamment \u00e0 forte dose et au long cours, sont pris en compte tant dans le r\u00e9gime alimentaire et dans les apports destin\u00e9s \u00e0 compenser certaines carences induites, qu\u2019en fonction des ant\u00e9c\u00e9dents m\u00e9dicaux (hypertension art\u00e9rielle, cataracte, ulc\u00e8re, diab\u00e8te, d\u00e9ficit immunitaire, infection grave r\u00e9cente\u2026.) et des possibles interactions m\u00e9dicamenteuses.<\/p>

Ils sont nombreux\u00a0: hypertension, diab\u00e8te, ost\u00e9oporose, glaucome, excitation et troubles du sommeil, gonflement et rougeur du visage, prise de poids, ecchymoses faciles, perte de masse musculaire, aggravation d\u2019un ulc\u00e8re, d\u2019un \u00e9tat d\u00e9pressif, d\u2019un d\u00e9ficit immunitaire, acn\u00e9\u2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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La Methylprednosolone\n\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Elle est administr\u00e9e en bolus de 500mg \u00e0 1g par perfusion et par jour, jusqu\u2019\u00e0 3 jours d\u2019affil\u00e9s en fonction de la s\u00e9v\u00e9rit\u00e9 de la pouss\u00e9e ou pour \u00e9viter certains effets secondaires et la corticod\u00e9pendance. La Prednisone est le traitement relais (oral) pris sur la base de 1 mg\/kg\/jour, en moyenne, dans un contexte de pouss\u00e9e, ou \u00e0 des doses plus faibles dans la seconde \u00e9ventualit\u00e9.<\/p>\n

Les m\u00e9decins cherchent \u00e0 trouver la dose d\u2019entretien la plus faible efficace (dose \u00ab seuil \u00bb) pour \u00e9viter les effets secondaires et la corticod\u00e9pendance.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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L\u2019information fournie sur ce site est destin\u00e9e \u00e0 faciliter la relation qui existe entre le patient et son m\u00e9decin, pas \u00e0 la remplacer.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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D\u00e9couvrez les autres types de traitements possibles :<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAnti-Inflammatoires<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tImmuno-suppresseurs<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAutres<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

L’ action des cortico\u00efdes est antalgique, anti-inflammatoire et immunosuppressive. Elle est identique \u00e0 celle des hormones cortico\u00efdes naturelles produites par les glandes surr\u00e9nales (cortisol). La pr\u00e9dnisone C’est le traitement de base de la PCA et de nombreuses autres maladies inflammatoires et auto-immunes. Administr\u00e9e par voie orale\u00a0: comprim\u00e9s dos\u00e9s \u00a0\u00e0 1mg, 5 mg et 20 mg. […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-506","page","type-page","status-publish","hentry","post"],"yoast_head":"\nLes Cortico\u00efdes - Association Francophone Contre La Polychondrite Chronique Atrophiante<\/title>\n<meta name=\"description\" content=\"la plupart des personnes atteintes de polychondrite chronique atrophiante re\u00e7oivent une dose de cortico\u00efde, la prednisone, qui est r\u00e9duite progressivement au fur et \u00e0 mesure de la diminution des sympt\u00f4mes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afpca.fr\/site\/les-corticoides\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les Cortico\u00efdes - 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