{"id":51,"date":"2021-03-11T14:13:15","date_gmt":"2021-03-11T13:13:15","guid":{"rendered":"http:\/\/afpcahome\/site\/?page_id=51"},"modified":"2023-12-18T18:37:39","modified_gmt":"2023-12-18T17:37:39","slug":"recherche","status":"publish","type":"page","link":"https:\/\/afpca.fr\/site\/recherche\/","title":{"rendered":"Recherche"},"content":{"rendered":"\t\t
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Il n\u2019y a encore pas si longtemps, les mots \u00ab polychondrite chronique atrophiante(PCA) \u00bb et \u00ab Recherche \u00bb \u00e9taient \u00e9trangers l\u2019un \u00e0 l\u2019autre. Comment une maladie aussi rare pouvait-elle int\u00e9resser un laboratoire de recherche ?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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L\u2019association et la recherche<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tEn parcourant Internet, notamment les sites m\u00e9dicaux, on s\u2019aper\u00e7oit que les rares publications parlant de cette maladie sont surtout descriptives (sympt\u00f4mes, \u00e9tudes de cas, traitements actuels\u2026) et ne traitent pratiquement pas de recherche.\n\nLors de sa cr\u00e9ation notre association s\u2019\u00e9tait, entre autres, fix\u00e9 pour objectif non seulement de sensibiliser le corps m\u00e9dical, mais aussi de mobiliser la recherche sur cette pathologie orpheline. Nous avions bien compris que cela devait passer par une forte implication dans le financement d\u2019un projet.\n\n \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Le d\u00e9but de la recherche sur la PCA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Gr\u00e2ce \u00e0 l\u2019aide de notre conseil scientifique, nous avons pu identifier le chercheur comp\u00e9tent susceptible de prendre en compte notre projet. C\u2019est ainsi que fin 2007, nous avons rencontr\u00e9 le professeur Guy Gorochov, chercheur au laboratoire d\u2019immunologie cellulaire et tissulaire de l\u2019INSERM, dirig\u00e9 par le professeur Patrice Debr\u00e9 \u00e0 la Piti\u00e9-Salp\u00eatri\u00e8re, pour le convaincre de franchir le pas avec nous.<\/p>

Le professeur Gorochov ne connaissait pas notre pathologie et savait que nous n\u2019avions pas encore le 1er euro pour financer ce projet. Mais \u00e9tait-ce notre d\u00e9termination, notre optimisme, le s\u00e9rieux de notre d\u00e9marche qui l\u2019ont convaincu de relever ce d\u00e9fi un peu fou ? En tout cas, nous sommes fiers d\u2019avoir pu m\u00e9riter sa confiance.<\/p>

Pour \u00eatre complets, il faut savoir qu\u2019il collaborait d\u00e9j\u00e0 (sur d\u2019autres projets) avec le service hospitalier qui poss\u00e8de sans doute la plus grande exp\u00e9rience clinique en mati\u00e8re de PCA et qu\u2019il comptait bien s\u2019appuyer sur cette mine de connaissances pour conduire notre projet. Nous faisons r\u00e9f\u00e9rence au service de m\u00e9decine interne du professeur Jean-Charles Piette du m\u00eame centre hospitalier de la Piti\u00e9.<\/p>

Le professeur Gorochov a propos\u00e9 au professeur Laurent Arnaud, ancien interne dans le service du professeur Piette, de se consacrer \u00e0 plein temps \u00e0 notre projet de recherche dans son laboratoire de l\u2019INSERM. Il a \u00e9t\u00e9 relay\u00e9 en 2014 par le professeur Makoto Miyara et le docteur Alexis Mathian.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Le r\u00f4le des chercheurs dans l\u2019association<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Chaque ann\u00e9e, lors de notre assembl\u00e9e annuelle, les chercheurs viennent pr\u00e9senter aux malades et \u00e0 leurs familles, les avanc\u00e9es dans le programme de recherche d\u00e9fini avec le bureau de l’AFPCA. Des pr\u00e9sentations sont disponibles dans l’espace adh\u00e9rent du forum.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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L\u2019objectif g\u00e9n\u00e9ral de la recherche sur la PCA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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L\u2019objectif g\u00e9n\u00e9ral est de d\u00e9couvrir un (ou des) marqueur(s) sp\u00e9cifique(s) \u00e0 la PCA pour \u00e9viter les ann\u00e9es d\u2019errance diagnostique qui causent une perte de temps souvent \u00e0 l\u2019origine de dommages physiques irr\u00e9versibles.<\/p>

Ce programme, qui a pour but de mieux comprendre les m\u00e9canismes responsables de la survenue de la PCA, utilise plusieurs approches compl\u00e9mentaires (immunologie cellulaire, g\u00e9n\u00e9tique et transcriptomique, culture plasmocytaire).<\/p>

Aucun traitement ne permettant aujourd\u2019hui de gu\u00e9rir la maladie, les malades r\u00eavent tous d\u2019une prise en charge et de traitements sp\u00e9cifiques plus efficaces. Nous formons l\u2019espoir que ce projet permettra aussi de progresser dans cette direction. Au fur et \u00e0 mesure de l\u2019avancement des travaux, nous tiendrons nos adh\u00e9rents inform\u00e9s sur cette page.<\/p>

Nos g\u00e9n\u00e9reux adh\u00e9rents et donateurs nous ont donc permis de donner corps \u00e0 ce projet inesp\u00e9r\u00e9 et d\u2019apporter le financement que nous nous effor\u00e7ons de p\u00e9renniser.<\/p>

M\u00eame si cela avance, le chemin est encore long. Mais cette maladie, si elle demeure orpheline, n\u2019est plus abandonn\u00e9e.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Pr\u00e9sentation du Pr. Guy GOROCHOV<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr. Guy GOROCHOV : Relapsing Polychondritis(RP) Study of pathogenesis Nominated by: Association Francophone contre la Polychondrite Chronique Atrophiante (AFPCA).<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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“Rare disease concerned: severe, episodic, and progressive inflammatory disease involving cartilaginous structures.<\/p>\n<\/div>\n<\/div>\n

The primary aim of this research is to improve our knowledge of the pathogenesis of RP, using a threefold (immunologi, epigenetic and in situ) dedicated approach.<\/p>\n

The first part of this project will study the expression of pro-inflammatory markers on the peripheral mononuclear cells (PBMCs) from 50 RP patients. This will draw new insights on the mechanisms involved in the recruitment of inflammatory infiltrates. The second part of this project focuses on epigenetics, studying the PBMCs transcriptome in RP patients. This will allow comparison of differentially expressed genes between patients and controls, providing a unique opportunity to identify a specific inflammatory signature in RP patients and to perform an in-depth study of cartilaginous inflammatory pathways. The third part of this project will use an original analytic strategy that allows us to define cytokine profiles of tissue-infiltrating T cells at a clonal level. This is based on the study of the T cell receptor (TCR) repertoire of cartilage-infiltrating T cells, and on the cytokine profile of each of these T cells. The data generated using this original approach will be used to identify the dominant T cell clones, as well as their functional orientation. This will be very helpful in studying the newly-recognized subsets of T helper cells named Th17 and Th22. The interactions between these cells and regulatory T cells are still poorly understood and may prove valuable targets for future therapies.<\/p>\n

Considering the fact that RP is an archetypal model of \u201cpure\u201d cartilaginous inflammation, these multiple approaches will provide a unique opportunity to decipher the pathways involved in cartilaginous inflammation. This is a critical issue not only to RP patients, but to all patients with more frequent rheumatic diseases such as rheumatoid arthritis or systemic lupus, as this may lead to development of new diagnostic tests and new treatments.”<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Il n\u2019y a encore pas si longtemps, les mots \u00ab polychondrite chronique atrophiante(PCA) \u00bb et \u00ab Recherche \u00bb \u00e9taient \u00e9trangers l\u2019un \u00e0 l\u2019autre. Comment une maladie aussi rare pouvait-elle int\u00e9resser un laboratoire de recherche ? L\u2019association et la recherche En parcourant Internet, notamment les sites m\u00e9dicaux, on s\u2019aper\u00e7oit que les rares publications parlant de cette […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-51","page","type-page","status-publish","hentry","post"],"yoast_head":"\nRecherche - Association Francophone Contre La Polychondrite Chronique Atrophiante<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afpca.fr\/site\/recherche\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recherche - Association Francophone Contre La Polychondrite Chronique Atrophiante\" \/>\n<meta property=\"og:description\" content=\"Il n\u2019y a encore pas si longtemps, les mots \u00ab polychondrite chronique atrophiante(PCA) \u00bb et \u00ab Recherche \u00bb \u00e9taient \u00e9trangers l\u2019un \u00e0 l\u2019autre. 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