{"id":510,"date":"2021-03-11T14:49:35","date_gmt":"2021-03-11T13:49:35","guid":{"rendered":"http:\/\/afpcahome\/site\/?page_id=510"},"modified":"2024-03-11T14:20:43","modified_gmt":"2024-03-11T13:20:43","slug":"les-anti-inflammatoires","status":"publish","type":"page","link":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/","title":{"rendered":"Les anti-inflammatoires"},"content":{"rendered":"\t\t
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Les anti-inflammatoires (AINS) sont utilis\u00e9s depuis de nombreuses ann\u00e9es pour traiter les rhumatismes inflammatoires et sont prescrits au moment des pouss\u00e9es et\/ou au long cours. Quelques-uns ont des propri\u00e9t\u00e9s anti-inflammatoires \u00e9quivalentes \u00e0 celles des corticost\u00e9ro\u00efdes, mais sans leurs effets secondaires st\u00e9ro\u00efdiens. Les AINS sont aussi antalgiques (antidouleurs) et antipyr\u00e9tiques (combattent la fi\u00e8vre).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"diet-pills-1328802_1280\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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M\u00e9canisme d'action<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Les AINS agissent tous sur les\u00a0<\/span>prostaglandines\u00a0<\/strong>qui sont un des m\u00e9diateurs cellulaires de l\u2019inflammation (chaleur, \u0153d\u00e8me et douleur). Ils inhibent une enzyme de d\u00e9gradation\u00a0: la\u00a0<\/span>COX\u00a0<\/strong>(Cyclo-Oxyg\u00e9nase) dont il existe deux formes\u00a0:<\/span><\/h2>

\u00a0 \u00a0\"s\"<\/span> la COX-1 <\/strong>pr\u00e9sente naturellement dans de nombreux tissus. Elle joue notamment un r\u00f4le protecteur de la muqueuse de l\u2019estomac et dans la coagulation sanguine ;\u00a0<\/p>

\u00a0 \u00a0\"s\"<\/span> la COX-2<\/strong> induite au niveau des sites inflammatoires avec exc\u00e8s de production locale de prostaglandines.<\/p>

Ces prostaglandines sont lib\u00e9r\u00e9es par des cellules inflammatoires et vont amplifier la r\u00e9action inflammatoire en attirant \u00e0 leur tour d\u2019autres cellules de l\u2019inflammation\u2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Classification<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Les AINS sont class\u00e9s en trois familles\u00a0:<\/p>

\u00a0 \u00a0<\/span>\"s\" l\u2019acide ac\u00e9tyl-salycilique (Aspirine), le plus ancien ;<\/span><\/p>

\u00a0 \u00a0\"s\" les AINS classiques\u00a0(non s\u00e9lectifs<\/strong>) tels\u00a0: le naproxen, le diclof\u00e9nac, l\u2019indom\u00e9thacine, le piroxicam, le tenoxicam, sont parfois efficaces pour contr\u00f4ler les polyarthralgies de la PCA (effet antalgique et parfois anti-inflammatoire). Ils inhibent \u00e0 la fois la production de la COX-1 et de la COX-2 ;<\/p>

Cette inhibition non s\u00e9lective explique les effets secondaires li\u00e9s aux prostaglandines, notamment les risques d\u2019h\u00e9morragies et d\u2019ulc\u00e8res digestifs par suppression des effets protecteurs et physiologiques de la COX-1.<\/p>

\u00a0 \u00a0\"s\" les AINS s\u00e9lectifs<\/strong> (famille des coxibs<\/strong>) tels le c\u00e9l\u00e9coxib et le nabum\u00e9tone qui inhibent la COX-2 seule, ce qui limite les effets secondaires habituels des AINS.\u00a0<\/p>

Leur efficacit\u00e9 est \u00e0 la fois d\u00e9pendante du dosage et du si\u00e8ge de l\u2019inflammation.\u00a0<\/p>

Les AINS sont souvent associ\u00e9s aux immunosuppresseurs et aux relaxants musculaires.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Deux types de dur\u00e9e d'action<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u00a0 \u00a0\"s\"\u00a0br\u00e8ve\u00a0: exemple l\u2019aspirine, le diclof\u00e9nac (50 \u00e0 200mg) ;<\/p>

\u00a0 \u00a0\"s\" longue : le piroxicam (20 \u00e0 40 mg, dur\u00e9e d\u2019action la plus longue), le diclof\u00e9nac sous forme Lib\u00e9ration Prolong\u00e9e (150 mg en 3 prises).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Contre-indications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Elles sont soit\u00a0absolues<\/strong>\u00a0(ulc\u00e8re en \u00e9volution, insuffisance r\u00e9nale ou h\u00e9patique, asthme…) soit\u00a0relatives<\/strong>.<\/p>

N\u00e9cessit\u00e9 d\u2019une surveillance clinique et biologique rigoureuse en tenant compte des ant\u00e9c\u00e9dents m\u00e9dicaux du patient.<\/span><\/p>

Du fait de leurs nombreuses interactions m\u00e9dicamenteuses et du risque d\u2019effets secondaires cumul\u00e9s, l\u2019association d\u2019AINS et de Cortico\u00efdes ou d\u2019Anticoagulants est interdite.<\/p>

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L\u2019information fournie sur ce site est destin\u00e9e \u00e0 faciliter la relation qui existe entre le patient et son m\u00e9decin\u00a0; <\/strong>pas \u00e0 la remplacer.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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D\u00e9couvrez les autres types de traitements possibles :<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tCortico\u00efdes<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tImmuno-suppresseurs<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAutres<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Les anti-inflammatoires (AINS) sont utilis\u00e9s depuis de nombreuses ann\u00e9es pour traiter les rhumatismes inflammatoires et sont prescrits au moment des pouss\u00e9es et\/ou au long cours. Quelques-uns ont des propri\u00e9t\u00e9s anti-inflammatoires \u00e9quivalentes \u00e0 celles des corticost\u00e9ro\u00efdes, mais sans leurs effets secondaires st\u00e9ro\u00efdiens. Les AINS sont aussi antalgiques (antidouleurs) et antipyr\u00e9tiques (combattent la fi\u00e8vre). M\u00e9canisme d’action Les […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-510","page","type-page","status-publish","hentry","post"],"yoast_head":"\nLes anti-inflammatoires - Association Francophone Contre La Polychondrite Chronique Atrophiante<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les anti-inflammatoires - Association Francophone Contre La Polychondrite Chronique Atrophiante\" \/>\n<meta property=\"og:description\" content=\"Les anti-inflammatoires (AINS) sont utilis\u00e9s depuis de nombreuses ann\u00e9es pour traiter les rhumatismes inflammatoires et sont prescrits au moment des pouss\u00e9es et\/ou au long cours. Quelques-uns ont des propri\u00e9t\u00e9s anti-inflammatoires \u00e9quivalentes \u00e0 celles des corticost\u00e9ro\u00efdes, mais sans leurs effets secondaires st\u00e9ro\u00efdiens. Les AINS sont aussi antalgiques (antidouleurs) et antipyr\u00e9tiques (combattent la fi\u00e8vre). 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Quelques-uns ont des propri\u00e9t\u00e9s anti-inflammatoires \u00e9quivalentes \u00e0 celles des corticost\u00e9ro\u00efdes, mais sans leurs effets secondaires st\u00e9ro\u00efdiens. Les AINS sont aussi antalgiques (antidouleurs) et antipyr\u00e9tiques (combattent la fi\u00e8vre). M\u00e9canisme d’action Les […]","og_url":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/","og_site_name":"Association Francophone Contre La Polychondrite Chronique Atrophiante","article_publisher":"https:\/\/www.facebook.com\/groups\/42710644010","article_modified_time":"2024-03-11T13:20:43+00:00","og_image":[{"url":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/elementor\/thumbs\/diet-pills-1328802_1280-p442zr9cuz4wx3znxv9z8319l4o2tt17acml9zk1yw.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/","url":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/","name":"Les anti-inflammatoires - Association Francophone Contre La Polychondrite Chronique Atrophiante","isPartOf":{"@id":"https:\/\/afpca.fr\/site\/#website"},"primaryImageOfPage":{"@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/#primaryimage"},"image":{"@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/#primaryimage"},"thumbnailUrl":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/elementor\/thumbs\/diet-pills-1328802_1280-p442zr9cuz4wx3znxv9z8319l4o2tt17acml9zk1yw.jpg","datePublished":"2021-03-11T13:49:35+00:00","dateModified":"2024-03-11T13:20:43+00:00","breadcrumb":{"@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/#primaryimage","url":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/elementor\/thumbs\/diet-pills-1328802_1280-p442zr9cuz4wx3znxv9z8319l4o2tt17acml9zk1yw.jpg","contentUrl":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/elementor\/thumbs\/diet-pills-1328802_1280-p442zr9cuz4wx3znxv9z8319l4o2tt17acml9zk1yw.jpg"},{"@type":"BreadcrumbList","@id":"https:\/\/afpca.fr\/site\/les-anti-inflammatoires\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/afpca.fr\/site\/"},{"@type":"ListItem","position":2,"name":"Les anti-inflammatoires"}]},{"@type":"WebSite","@id":"https:\/\/afpca.fr\/site\/#website","url":"https:\/\/afpca.fr\/site\/","name":"Association Francophone Contre La Polychondrite Chronique Atrophiante","description":"Association Francophone Contre La Polychondrite Chronique Atrophiante","publisher":{"@id":"https:\/\/afpca.fr\/site\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/afpca.fr\/site\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/afpca.fr\/site\/#organization","name":"Association Francophone Contre La Polychondrite Chronique Atrophiante","url":"https:\/\/afpca.fr\/site\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/afpca.fr\/site\/#\/schema\/logo\/image\/","url":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/2023\/05\/LOGO_afpca.png","contentUrl":"https:\/\/afpca.fr\/site\/wp-content\/uploads\/2023\/05\/LOGO_afpca.png","width":184,"height":184,"caption":"Association Francophone Contre La Polychondrite Chronique Atrophiante"},"image":{"@id":"https:\/\/afpca.fr\/site\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/groups\/42710644010"]}]}},"_links":{"self":[{"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/pages\/510","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/comments?post=510"}],"version-history":[{"count":0,"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/pages\/510\/revisions"}],"wp:attachment":[{"href":"https:\/\/afpca.fr\/site\/wp-json\/wp\/v2\/media?parent=510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}