{"id":714,"date":"2021-03-12T14:28:03","date_gmt":"2021-03-12T13:28:03","guid":{"rendered":"http:\/\/afpcahome\/site\/?page_id=714"},"modified":"2024-03-14T10:54:35","modified_gmt":"2024-03-14T09:54:35","slug":"les-immunosuppresseurs","status":"publish","type":"page","link":"https:\/\/afpca.fr\/site\/les-immunosuppresseurs\/","title":{"rendered":"Les immunosuppresseurs"},"content":{"rendered":"\t\t
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Les immunosuppresseurs ont une action anti-inflammatoire puissante et sont utilis\u00e9s dans le traitement des maladies auto-immunes telles la Polyarthrite Rhumato\u00efde, la Spondylarthrite Ankylosante, le Lupus Eryth\u00e9mateux Diss\u00e9min\u00e9\u2026.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"medication\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Ils sont indiqu\u00e9s en cas de cortico-d\u00e9pendance afin de r\u00e9duire les doses de cortico\u00efdes et, ainsi, de limiter les complications li\u00e9es \u00e0 cette th\u00e9rapie.
Destin\u00e9s initialement au traitement d\u2019autres maladies, comme le cancer ou la pr\u00e9vention du rejet de greffes\u00a0; ils ont une action non sp\u00e9cifique. Ils n\u2019\u00e9pargnent donc pas les cellules saines et entra\u00eenent de nombreux effets secondaires. Ceci n\u00e9cessite le respect strict de leurs contre-indications, une surveillance r\u00e9guli\u00e8re clinique, biologique (h\u00e9mogramme, bilan h\u00e9patique et r\u00e9nal) et respiratoire\u2026<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Les M\u00e9thotrexate<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Analogue et antagoniste de l\u2019acide folique ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Le mieux tol\u00e9r\u00e9 et le plus prescrit avec une efficacit\u00e9 inconstante mais r\u00e9elle, permettant de r\u00e9duire les doses de cortico\u00efdes de fa\u00e7on significative ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Le plus souvent utilis\u00e9 \u00e0 la dose initiale moyenne de 17.5 mg\/semaine ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Ses effets secondaires sont d\u2019ordre h\u00e9matologique, digestif, h\u00e9patique, pulmonaire et r\u00e9nal ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Voie orale (une seule prise hebdomadaire) ou en injection sous-cutan\u00e9e ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Correction de la carence vitaminique induite, par prescription d\u2019acide folique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Le Cyclophosphamide<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Agent alkylant de la famille des moutardes azot\u00e9es ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Voie orale ou perfusions mensuelles indiqu\u00e9es dans les formes plus s\u00e9v\u00e8res ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Bonne tol\u00e9rance g\u00e9n\u00e9rale et locale mais nombreuses pr\u00e9cautions d’emploi notamment contraception efficace pour les 2 sexes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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L\u2019Azathioprine<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Analogue de l\u2019hypoxanthine ;
<\/span>\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Utilis\u00e9 \u00e0 des doses moindres que dans la pr\u00e9vention du rejet de greffes ;
<\/span>\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Dose moyenne autour de 2 \u00e0 3 cp\/jour ;
<\/span>\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Ef<\/span>fets secondaires les plus fr\u00e9quents\u00a0de nature h\u00e9matologique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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La Ciclosporine<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Immunosuppresseur<\/span>\u00a0puissant, utilis\u00e9e pour \u00e9viter le rejet de greffes ;
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Inhibition de l\u2019activation lymphocytaire T ;\u00a0
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Doses habituelles entre 3 et 5 mg\/kg ;\u00a0
\u00a0 \u00a0\u00a0\"s\"<\/span>\u00a0Effets secondaires nombreux, essay\u00e9e en cas d\u2019\u00e9chec des autres IS.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Le Mycoph\u00e9nolate Mofetil<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\"s\"<\/span> Anti-inflammatoire et IS par inhibition de la prolif\u00e9ration lymphocytaire et la synth\u00e8se d\u2019anticorps ;
\"s\"<\/span> Prescrit dans la pr\u00e9vention des rejets de greffe \u00e0 plus fortes doses ;
\"s\"<\/span> Effets secondaires nombreux. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Il peut se passer plusieurs semaines voire plusieurs mois avant que ces m\u00e9dicaments ne produisent un effet b\u00e9n\u00e9fique. Le temps que cet effet se manifeste, la prise d\u2019un AINS ou le plus souvent de corticost\u00e9ro\u00efdes \u00e0 la dose la plus faible efficace (dose seuil) est associ\u00e9e.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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L\u2019information fournie sur ce site est destin\u00e9e \u00e0 faciliter la relation qui existe entre le patient et son m\u00e9decin\u00a0; <\/strong>pas \u00e0 la remplacer<\/strong>.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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D\u00e9couvrez les autres types de traitements possibles :<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tCortico\u00efdes<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAnti-Inflammatoires<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tAutres<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Les immunosuppresseurs ont une action anti-inflammatoire puissante et sont utilis\u00e9s dans le traitement des maladies auto-immunes telles la Polyarthrite Rhumato\u00efde, la Spondylarthrite Ankylosante, le Lupus Eryth\u00e9mateux Diss\u00e9min\u00e9\u2026. Ils sont indiqu\u00e9s en cas de cortico-d\u00e9pendance afin de r\u00e9duire les doses de cortico\u00efdes et, ainsi, de limiter les complications li\u00e9es \u00e0 cette th\u00e9rapie.Destin\u00e9s initialement au traitement d\u2019autres […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-714","page","type-page","status-publish","hentry","post"],"yoast_head":"\nLes immunosuppresseurs - Association Francophone Contre La Polychondrite Chronique Atrophiante<\/title>\n<meta name=\"description\" content=\"l'utilisation des Immunosuppresseurs dans le traitement de la polychondrite chronique atrophiante.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/afpca.fr\/site\/les-immunosuppresseurs\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Les immunosuppresseurs - 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